FEATURES OF HEART DAMAGE IN PATIENTS WITH VIRAL CIRRHOSIS OF THE LIVER
Keywords:
left ventricle, viral cirrhosis of the liver, antiviral therapy.Abstract
The study analyzed the results of a survey of 96 patients (51% men, 49% women) with viral cirrhosis of the liver of class A, B, C according to Child-Pugh criteria, who were treated at the City Infectious Diseases Hospital in Chita. The median age of the patients was 42.1 [36;44] years, the duration of the disease was 3.5 [2.8;6.7] years. The diagnosis of CL was confirmed morphologically (laparoscopy with targeted biopsy) in 9 people, the rest of them were exposed on the basis of clinical, laboratory and instrumental data. The viral genesis of liver damage was confirmed by the presence of markers of viral hepatitis B in the blood serum [HBsAg, antibodies (AT) of classes M and G to HbcorAg, HBV DNA), C (AT of classes M and G to HCV, HCV RNA]. Depending on the presence of ascites, the patients were divided into 2 groups: 59 (61%) patients did not have ascites (group 1), 37 (38%) patients were diagnosed with ascites of varying severity (group 2), the control group consisted of 21 healthy volunteers of the corresponding age without signs of liver pathology. The study did not include: patients older than 52 years with essential and symptomatic arterial hypertension, heart and lung diseases, with chronic alcoholism and severe concomitant pathology. Thus, in patients with ICP without ascites, an increase in the mass of the left ventricular myocardium, the left atrium cavity, and the pulmonary artery was found, there is a violation of the heart rhythm and an elongation of the corrected QT interval. These changes were more pronounced in patients with ascites, in addition, they had increased pressure in the pulmonary artery and decreased systolic function of the heart's ventricles. Antiviral therapy has a positive effect on some cardiohemodynamic parameters.
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